Chemokines have a central role in regulating processes essential to the immune function of
T cells 1 , 2 , 3 , such as their migration within lymphoid tissues and targeting of pathogens in …

Type 2 inflammation underlies allergic diseases such as atopic dermatitis, which is characterized
by the accumulation of basophils and group 2 innate lymphoid cells (ILC2s) in inflamed …

Eosinophilic esophagitis (EoE) is a food allergy–associated inflammatory disease characterized
by esophageal eosinophilia. Current management strategies for EoE are nonspecific, …

Interferon-γ (IFN-γ) promotes a population of T-bet + CXCR3 + regulatory T (Treg) cells that
limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL…

Group 2 innate lymphoid cells (ILC2s) regulate tissue inflammation and repair after
activation by cell-extrinsic factors such as host-derived cytokines. However, the cell-intrinsic …

The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …

European and North American strains of the parasite Toxoplasma gondii belong to three
distinct clonal lineages, type I, type II, and type III, which differ in virulence. Understanding the …

Innate lymphoid cells (ILCs) are innate immune cells that are ubiquitously distributed in
lymphoid and nonlymphoid tissues and enriched at mucosal and barrier surfaces. Three major …

Innate lymphoid cells (ILCs) are a recently described group of innate immune cells that can
regulate immunity, inflammation, and tissue repair in multiple anatomical compartments, …

IL-27 is a cytokine that regulates Th function during autoimmune and pathogen-induced
immune responses. Although previous studies have shown that regulatory T cells (Tregs) …