The blood–brain barrier (BBB) is a tightly regulated interface in the Central Nervous System
(CNS) that regulates the exchange of molecules in and out from the brain thus maintaining …

Astrocytes play an important role in physiological, metabolic, and structural functions, and
when impaired, they can be involved in various pathologies including Alzheimer, focal …

Tibolone, a synthetic steroid used for the prevention of osteoporosis and the treatment of
climacteric symptoms in post-menopausal women, may exert tissue selective estrogenic actions …

Cacao (Theobroma cacao L.), the source of chocolate, is one of the most important commodity
products worldwide that helps improve the economic livelihood of farmers. Diseases like …

The translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine
receptor (PBR), is considered an important regulator of steroidogenesis and a potential …

Previous studies have indicated that mesenchymal stem cells (MSCs) have a fundamental
role in the repair and regeneration of damaged tissues. There is strong evidence showing that …

High concentrations of palmitic acid in plasma increase both the inflammation associated
with obesity and the susceptibility to develop a neurodegenerative event. In the brain, the …

Neurodegenerative diseases, such as Parkinson and Alzheimer, are among the main public
health issues in the world due to their effects on life quality and high mortality rates. …

Synthetic selective modulators of the estrogen receptors (SERMs) have shown to protect
neurons and glial cells against toxic insults. Among the most relevant beneficial effects …

Previous studies have indicated that paracrine factors (conditioned medium) increase
wound closure and reduce reactive oxygen species in a traumatic brain injury in vitro model. …