Collective cell migration is essential for morphogenesis, tissue remodelling and cancer
invasion 1 , 2 . In vivo, groups of cells move in an orchestrated way through tissues. This …

Embryogenesis, tissue repair and cancer metastasis rely on collective cell migration. In vitro
studies propose that cells are stiffer while migrating in stiff substrates, but softer when plated …

Connexins are the primary components of gap junctions, providing direct links between
cells under many physiological processes. Here, we demonstrate that in addition to this …

One of the most important mechanisms that promotes metastasis is the stabilization of Hif-1 (hypoxia-inducible
transcription factor 1). We decided to test whether Hif-1α also was …

Cell migration is essential for a wide range of biological processes such as embryo
morphogenesis, wound healing, regeneration, and also in pathological conditions, such as cancer. …

Directed cell migration is essential for cells to efficiently migrate in physiological and
pathological processes. While migrating in their native environment, cells interact with multiple …

Cell shape is controlled by the submembranous cortex, an actomyosin network mainly generated
by two actin nucleators: the Arp2/3 complex and the formin mDia1. Changes in relative …

The neural crest is a uniquely vertebrate cell type and has been well studied in a number of
model systems. Zebrafish, Xenopus and chick embryos largely show consistent …

A fundamental property of neural crest (NC) migration is contact inhibition of locomotion (CIL),
a process by which cells change their direction of migration upon cell contact. CIL has …

Growth hormone receptor (GHR) is a critical regulator of growth and metabolism. Although
two GHRs have been characterized in many fish species, their functional characteristics, …