Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo
Collective cell migration is essential for morphogenesis, tissue remodelling and cancer
invasion 1 , 2 . In vivo, groups of cells move in an orchestrated way through tissues. This …
invasion 1 , 2 . In vivo, groups of cells move in an orchestrated way through tissues. This …
[HTML][HTML] Cell clusters softening triggers collective cell migration in vivo
…, AN Malmi-Kakkada, JA Espina, EH Barriga - Nature Materials, 2022 - nature.com
Embryogenesis, tissue repair and cancer metastasis rely on collective cell migration. In vitro
studies propose that cells are stiffer while migrating in stiff substrates, but softer when plated …
studies propose that cells are stiffer while migrating in stiff substrates, but softer when plated …
[HTML][HTML] Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo
Connexins are the primary components of gap junctions, providing direct links between
cells under many physiological processes. Here, we demonstrate that in addition to this …
cells under many physiological processes. Here, we demonstrate that in addition to this …
The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition
EH Barriga, PH Maxwell, AE Reyes, R Mayor - Journal of Cell Biology, 2013 - rupress.org
One of the most important mechanisms that promotes metastasis is the stabilization of Hif-1 (hypoxia-inducible
transcription factor 1). We decided to test whether Hif-1α also was …
transcription factor 1). We decided to test whether Hif-1α also was …
[HTML][HTML] Adjustable viscoelasticity allows for efficient collective cell migration
EH Barriga, R Mayor - Seminars in cell & developmental biology, 2019 - Elsevier
Cell migration is essential for a wide range of biological processes such as embryo
morphogenesis, wound healing, regeneration, and also in pathological conditions, such as cancer. …
morphogenesis, wound healing, regeneration, and also in pathological conditions, such as cancer. …
Durotaxis: the mechanical control of directed cell migration
JA Espina, CL Marchant, EH Barriga - The FEBS journal, 2022 - Wiley Online Library
Directed cell migration is essential for cells to efficiently migrate in physiological and
pathological processes. While migrating in their native environment, cells interact with multiple …
pathological processes. While migrating in their native environment, cells interact with multiple …
SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization
Cell shape is controlled by the submembranous cortex, an actomyosin network mainly generated
by two actin nucleators: the Arp2/3 complex and the formin mDia1. Changes in relative …
by two actin nucleators: the Arp2/3 complex and the formin mDia1. Changes in relative …
Animal models for studying neural crest development: is the mouse different?
The neural crest is a uniquely vertebrate cell type and has been well studied in a number of
model systems. Zebrafish, Xenopus and chick embryos largely show consistent …
model systems. Zebrafish, Xenopus and chick embryos largely show consistent …
PDGF controls contact inhibition of locomotion by regulating N-cadherin during neural crest migration
I Bahm, EH Barriga, A Frolov, E Theveneau… - …, 2017 - journals.biologists.com
A fundamental property of neural crest (NC) migration is contact inhibition of locomotion (CIL),
a process by which cells change their direction of migration upon cell contact. CIL has …
a process by which cells change their direction of migration upon cell contact. CIL has …
Growth hormone receptors in zebrafish (Danio rerio): adult and embryonic expression patterns
CM Di Prinzio, PE Botta, EH Barriga, EA Ríos… - Gene Expression …, 2010 - Elsevier
Growth hormone receptor (GHR) is a critical regulator of growth and metabolism. Although
two GHRs have been characterized in many fish species, their functional characteristics, …
two GHRs have been characterized in many fish species, their functional characteristics, …