Fibrosis is associated with organ failure and high mortality and is commonly characterized
by aberrant myofibroblast accumulation. Investigating the cellular origin of myofibroblasts in …

The early mouse embryonic lung, with its robust and apparently reproducible branching
pattern, has always fascinated developmental biologists. They have extensively used this …

Idiopathic pulmonary fibrosis (IPF) is a form of progressive interstitial lung disease with unknown
etiology. Due to a lack of effective treatment, IPF is associated with a high mortality rate. …

Basic research on embryonic lung development offers unique opportunities to make important
discoveries that will impact human health. Developmental biologists interested in the …

Increasing evidence suggests that neurogenesis occurs in the postnatal and adult mammalian
hypothalamus. However, the identity and location of the putative progenitor cells is under …

The lung mesenchyme consists of a widely heterogeneous population of cells that play crucial
roles during development and homeostasis after birth. These cells belong to myogenic, …

Influenza Virus (IV) pneumonia is associated with severe damage of the lung epithelium
and respiratory failure. Apart from efficient host defense, structural repair of the injured …

Background Recent clinical studies show that tyrosine kinase inhibitors slow the rate of lung
function decline and decrease the number of acute exacerbations in patients with Idiopathic …

Idiopathic pulmonary fibrosis (IPF) is a fatal disease in which the intricate alveolar network of
the lung is progressively replaced by fibrotic scars. Myofibroblasts are the effector cells that …

The lung harbors its basal stem/progenitor cells (BSCs) in the protected environment of the
cartilaginous airways. After major lung injuries, BSCs are activated and recruited to sites of …