User profiles for Elie N. Farah

Elie Farah

Postdoctoral Scholar, UC San Diego
Verified email at health.ucsd.edu
Cited by 722

Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells

…, T Li, S Preissl, ML Amaral, JD Grinstein, EN Farah… - Nature …, 2019 - nature.com
Chromatin architecture has been implicated in cell type-specific gene regulatory programs,
yet how chromatin remodels during development remains to be fully elucidated. Here, by …

Cardiac cell type–specific gene regulatory programs and disease risk association

…, Q Zhang, X Hou, YE Li, Y Zhang, EN Farah… - Science …, 2021 - science.org
Misregulated gene expression in human hearts can result in cardiovascular diseases that
are leading causes of mortality worldwide. However, the limited information on the genomic …

[PDF][PDF] Canonical Wnt5b signaling directs outlying Nkx2. 5+ mesoderm into pacemaker cardiomyocytes

J Ren, P Han, X Ma, EN Farah, J Bloomekatz… - Developmental cell, 2019 - cell.com
Pacemaker cardiomyocytes that create the sinoatrial node are essential for the initiation and
maintenance of proper heart rhythm. However, illuminating developmental cues that direct …

Combinatorial interactions of genetic variants in human cardiomyopathy

…, T Li, ND Dalton, Q Peng, EN Farah… - Nature biomedical …, 2019 - nature.com
Dilated cardiomyopathy (DCM) is a leading cause of morbidity and mortality worldwide; yet
how genetic variation and environmental factors impact DCM heritability remains unclear. …

[PDF][PDF] Cell-surface marker signature for enrichment of ventricular cardiomyocytes derived from human embryonic stem cells

J Veevers, EN Farah, M Corselli, AD Witty… - Stem cell reports, 2018 - cell.com
To facilitate understanding of human cardiomyocyte (CM) subtype specification, and the
study of ventricular CM biology in particular, we developed a broadly applicable strategy for …

[HTML][HTML] Spatially organized cellular communities form the developing human heart

EN Farah, RK Hu, C Kern, Q Zhang, TY Lu, Q Ma… - Nature, 2024 - nature.com
The heart, which is the first organ to develop, is highly dependent on its form to function 1, 2.
However, how diverse cardiac cell types spatially coordinate to create the complex …

3D chromatin architecture remodeling during human cardiomyocyte differentiation reveals a novel role of HERV-H in demarcating chromatin domains

Y Zhang, T Li, S Preissl, J Grinstein, EN Farah… - BioRxiv, 2018 - biorxiv.org
Restructuring of chromatin architecture is an essential process for establishing cell type-specific
gene regulatory programs in eukaryotic cells including cardiomyocytes 1 – 3 . …

Human-gained heart enhancers are associated with species-specific cardiac attributes

E Destici, F Zhu, S Tran, S Preissl, EN Farah… - Nature cardiovascular …, 2022 - nature.com
Heart development is controlled by a relatively conserved network of transcriptional and
chromatin regulators; how the human heart has evolved species-specific features to maintain …

Cell Layers: uncovering clustering structure in unsupervised single-cell transcriptomic analysis

AP Blair, RK Hu, EN Farah, NC Chi… - Bioinformatics …, 2022 - academic.oup.com
Motivation Unsupervised clustering of single-cell transcriptomics is a powerful method for
identifying cell populations. Static visualization techniques for single-cell clustering only …

Cell Layers: Uncovering clustering structure and knowledge in unsupervised single-cell transcriptomic analysis

AP Blair, RK Hu, EN Farah, NC Chi, KS Pollard… - bioRxiv, 2020 - biorxiv.org
Motivation Unsupervised clustering of single-cell transcriptomics is a powerful method for
identifying cell populations. Static visualization techniques for single-cell clustering only …