User profiles for Elijah S. Lawrence

Elijah S Lawrence

Duke University School of Medicine - Medical Scientist Training Program (MD-PhD) Student
Verified email at duke.edu
Cited by 553

[HTML][HTML] Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission

…, ES Cresini, ER Eisner, AL Lastrella, ES Lawrence… - Nature, 2022 - nature.com
As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical
for public health interventions. Inferring lineage prevalence by clinical testing is infeasible …

Functional EPAS1/HIF2A missense variant is associated with hematocrit in Andean highlanders

ES Lawrence, W Gu, RJ Bohlender… - Science …, 2024 - science.org
Hypoxia-inducible factor pathway genes are linked to adaptation in both human and
nonhuman highland species. EPAS1, a notable target of hypoxia adaptation, is associated with …

[HTML][HTML] Time domains of hypoxia responses and-omics insights

…, W Gu, J Alcock, EA Moya, ES Lawrence… - Frontiers in …, 2022 - frontiersin.org
The ability to respond rapidly to changes in oxygen tension is critical for many forms of life.
Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and …

[HTML][HTML] Safer at school early alert: an observational study of wastewater and surface monitoring to detect COVID-19 in elementary schools

…, C Hobbs, AL Lastrella, ES Lawrence… - The Lancet Regional …, 2023 - thelancet.com
Background Schools are high-risk settings for SARS-CoV-2 transmission, but necessary for
children's educational and social-emotional wellbeing. Previous research suggests that …

Genetic variants at the EGLN1 locus associated with high‐altitude adaptation in Tibetans are absent or found at low frequency in highland Andeans

EC Heinrich, L Wu, ES Lawrence… - Annals of Human …, 2019 - Wiley Online Library
EGLN1 encodes the hypoxia‐inducible factor (HIF) pathway prolyl hydroxylase 2 (PHD2)
that serves as an oxygen‐sensitive regulator of HIF activity. The EGLN1 locus exhibits a …

Combined intermittent and sustained hypoxia is a novel and deleterious cardio-metabolic phenotype

X Zhen, EA Moya, M Gautane, H Zhao, ES Lawrence… - Sleep, 2022 - academic.oup.com
Study Objectives Chronic obstructive pulmonary disease and obstructive sleep apnea overlap
syndrome is associated with excess mortality, and outcomes are related to the degree of …

Analysis of SARS-CoV-2 RNA persistence across indoor surface materials reveals best practices for environmental monitoring programs

…, CA Ruiz, CA Marotz, D Maunder, ES Lawrence… - Msystems, 2021 - Am Soc Microbiol
Environmental monitoring in public spaces can be used to identify surfaces contaminated
by persons with coronavirus disease 2019 (COVID-19) and inform appropriate infection …

SARS-CoV-2 Distribution in Residential Housing Suggests Contact Deposition and Correlates with Rothia sp.

…, A Hakim, L Kohn, AL Lastrella, ES Lawrence… - Msystems, 2022 - Am Soc Microbiol
Monitoring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on surfaces is
emerging as an important tool for identifying past exposure to individuals shedding viral RNA. …

Genomic surveillance reveals dynamic shifts in the connectivity of COVID-19 epidemics

…, J Wilson, SN Ngo, A Plascencia, ES Lawrence… - Cell, 2023 - cell.com
The maturation of genomic surveillance in the past decade has enabled tracking of the
emergence and spread of epidemics at an unprecedented level. During the COVID-19 pandemic, …

[HTML][HTML] Seq-ing higher ground: functional investigation of adaptive variation associated with high-altitude adaptation

JE Hall, ES Lawrence, TS Simonson, K Fox - Frontiers in Genetics, 2020 - frontiersin.org
Human populations at high altitude exhibit both unique physiological responses and strong
genetic signatures of selection thought to compensate for the decreased availability of …