Mitochondrial dysfunction is implicated in Parkinson disease (PD). Mutations in Parkin, an
E3 ubiquitin ligase, can cause juvenile-onset Parkinsonism, probably through impairment of …

The quality control of mitochondria is critical for the survival of cells, and defects in the
pathways required for this quality control can lead to severe disease. A key quality control …

Dementia with Lewy bodies (DLB) patients frequently experience well formed recurrent
complex visual hallucinations (RCVH). This is associated with reduced blood flow or …

Production of Aβ by γ‐secretase is a key event in A lzheimer's disease (AD). The γ‐secretase
complex consists of presenilin ( PS ) 1 or 2, nicastrin (ncstn), P en‐2, and A ph‐1 and …

The abnormal assembly of tau protein in neurons is the pathological hallmark of multiple
neurodegenerative diseases, including Alzheimer's disease (AD). Assembled tau also …

Ageing is a natural process, which is characterised by progressive decline in physiological
functions and increased susceptibility to disease and death. Brain is particularly susceptible …

Carbon monoxide (CO) is a colourless, odourless gas that in high concentration can be fatal,
and in low concentrations can lead to a variety of symptoms, including nausea, confusion, …

… Kerrie Brusby has been a source of extracurricular events and activities while Eliona Tsefou
has selflessly provided her help on numerous occasions and the completion of this thesis …

The two studies reported in this issue are from three experimental groups who each used
different methods of producing, cooling, and mass-selecting the large protonated water clusters…

Our environment and diet contains a variety of man-made endocrine disrupting chemicals
which may pose a significant health threat for wildlife and humans. In particular, there is …