Extracellular vesicles and exomere nanoparticles are under intense investigation as
sources of clinically relevant cargo. Here we report the discovery of a distinct extracellular …

Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular
heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights …

Exomeres are a recently discovered type of extracellular nanoparticle with no known biological
function. Herein, we describe a simple ultracentrifugation-based method for separation of …

Highly multiplexed tissue imaging makes detailed molecular analysis of single cells possible
in a preserved spatial context. However, reproducible analysis of large multichannel …

Background & Aims Countries endemic for parasitic infestations have a lower incidence of
Crohn’s disease (CD) than nonendemic countries, and there have been anecdotal reports of …

Modern single-cell technologies allow multiplexed sampling of cellular states within a tissue.
However, computational tools that can infer developmental cell-state transitions …

Intestinal tuft cells are a rare, poorly understood cell type recently shown to be a critical
mediator of type 2 immune response to helminth infection. Here, we present advances in …

Background Non-invasive imaging biomarkers of cellular proliferation hold great promise
for quantifying response to personalized medicine in oncology. An emerging approach to …

Objective. The volume of subcutaneous xenograft tumors is an important metric of disease
progression and response to therapy in preclinical drug development. Noninvasive imaging …

Purpose A temporal diffusion MRI spectroscopy based approach has been developed to
quantify cancer cell size and density in vivo. Methods A novel imaging microstructural …