A global decrease in microRNA (miRNA) levels is often observed in human cancers 1 , 2 ,
indicating that small RNAs may have an intrinsic function in tumour suppression. To identify …

Alternative splicing modulates the expression of many oncogene and tumor-suppressor
isoforms. We have tested whether some alternative splicing factors are involved in cancer. We …

The adenovirus E1A oncogene activates p53 through a signaling pathway involving the
retinoblastoma protein and the tumor suppressor p19 ARF . The ability of E1A to induce p53 and …

Some cancers evade targeted therapies through a mechanism known as lineage plasticity,
whereby tumor cells acquire phenotypic characteristics of a cell lineage whose survival no …

… In addition, we find that hypoxic cells bypass de novo lipogenesis, and thus, both the need
for … Hypoxic reprogramming of de novo lipogenesis can be reproduced in normoxic cells by …

Continued reliance on the androgen receptor (AR) is now understood as a core mechanism
in castration-resistant prostate cancer (CRPC), the most advanced form of this disease. …

The insulin-like growth factor 1 (IGF-1)-AKT-mTOR pathways sense the availability of nutrients
and mitogens and respond by signaling for cell growth and division. The p53 pathway …

EGF receptor (EGFR)–mutant lung cancers eventually become resistant to treatment with
EGFR tyrosine kinase inhibitors (TKI). The combination of EGFR-TKI afatinib and anti-EGFR …

Metastasis frequently develops years after the removal of a primary tumor, from a minority of
disseminated cancer cells that survived as latent entities through unknown mechanisms. We …

Chromosomal rearrangements have a central role in the pathogenesis of human cancers
and often result in the expression of therapeutically actionable gene fusions 1 . A recently …