[PDF][PDF] Structural basis of egg coat-sperm recognition at fertilization
I Raj, HS Al Hosseini, E Dioguardi, K Nishimura, L Han… - Cell, 2017 - cell.com
Recognition between sperm and the egg surface marks the beginning of life in all sexually
reproducing organisms. This fundamental biological event depends on the species-specific …
reproducing organisms. This fundamental biological event depends on the species-specific …
[HTML][HTML] Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility
Mammalian fertilisation begins when sperm interacts with the egg zona pellucida (ZP), whose
ZP1 subunit is important for fertility by covalently cross-linking ZP filaments into a three-…
ZP1 subunit is important for fertility by covalently cross-linking ZP filaments into a three-…
[HTML][HTML] Easy mammalian expression and crystallography of maltose-binding protein-fused human proteins
M Bokhove, HS Al Hosseini, T Saito, E Dioguardi… - Journal of structural …, 2016 - Elsevier
We present a strategy to obtain milligrams of highly post-translationally modified eukaryotic
proteins, transiently expressed in mammalian cells as rigid or cleavable fusions with a …
proteins, transiently expressed in mammalian cells as rigid or cleavable fusions with a …
[PDF][PDF] ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat
…, C Emori, B Wiseman, D Fahrenkamp, E Dioguardi… - Cell, 2024 - cell.com
Following the fertilization of an egg by a single sperm, the egg coat or zona pellucida (ZP)
hardens and polyspermy is irreversibly blocked. These events are associated with the …
hardens and polyspermy is irreversibly blocked. These events are associated with the …
Architecture of the vertebrate egg coat and structural basis of the ZP2 block to polyspermy
…, C Emori, B Wiseman, D Fahrenkamp, E Dioguardi… - bioRxiv, 2023 - biorxiv.org
Post-fertilization cleavage of glycoprotein ZP2, a major subunit of egg zona pellucida (ZP)
filaments, is crucial for mammalian reproduction by irreversibly blocking polyspermy. ZP2 …
filaments, is crucial for mammalian reproduction by irreversibly blocking polyspermy. ZP2 …
[HTML][HTML] A 'multiomic'approach of saliva metabolomics, microbiota, and serum biomarkers to assess the need of hospitalization in coronavirus disease 2019
…, A Darwich, I Spadoni, B Oresta, CC Dioguardi… - Gastro Hep …, 2022 - Elsevier
Background and Aims The SARS-CoV-2 pandemic has overwhelmed the treatment capacity
of the health care systems during the highest viral diffusion rate. Patients reaching the …
of the health care systems during the highest viral diffusion rate. Patients reaching the …
Structural studies of proteins essential for fertilization
E Dioguardi - 2018 - search.proquest.com
Where do babies come from? Even though it sounds like a fairly obvious question, it took
more than 200 years to discover that sperm, whose first observation dates back to the 17th …
more than 200 years to discover that sperm, whose first observation dates back to the 17th …
[HTML][HTML] Gut microbiota functional dysbiosis relates to individual diet in subclinical carotid atherosclerosis
A Baragetti, M Severgnini, E Olmastroni, CC Dioguardi… - Nutrients, 2021 - mdpi.com
Gut Microbiota (GM) dysbiosis associates with Atherosclerotic Cardiovascular Diseases (ACVD),
but whether this also holds true in subjects without clinically manifest ACVD represents …
but whether this also holds true in subjects without clinically manifest ACVD represents …
Evaluation of waterborne exposure to heavy metals in innate immune defences present on skin mucus of gilthead seabream (Sparus aurata)
FA Guardiola, M Dioguardi, MG Parisi… - Fish & shellfish …, 2015 - Elsevier
Aquatic animals are continuously exposed to chemical pollutants but the effects evoked in
skin surfaces, which receive the most direct contact with them, are poorly investigated. …
skin surfaces, which receive the most direct contact with them, are poorly investigated. …
ProCoCoA: a quantitative approach for analyzing protein core composition
…, D Garlaschelli, O Spiga, M Dioguardi… - … biology and chemistry, 2013 - Elsevier
Defining the amino acid composition of protein cores is fundamental for understanding protein
folding, as different architectures might achieve structural stability only in the presence of …
folding, as different architectures might achieve structural stability only in the presence of …