The SIGnaling Network Open Resource 2.0 (SIGNOR 2.0) is a public repository that stores
signaling information as binary causal relationships between biological entities. The captured …

Upon chronic antigen exposure, CD8 + T cells become exhausted, acquiring a dysfunctional
state correlated with the inability to control infection or tumor progression. In contrast, stem-…

Fibro/Adipogenic Progenitors (FAPs) are muscle-interstitial progenitors mediating pro-myogenic
signals that are critical for muscle homeostasis and regeneration. In myopathies, the …

Fibro-adipogenic progenitors (FAPs) promote satellite cell differentiation in adult skeletal
muscle regeneration. However, in pathological conditions, FAPs are responsible for fibrosis …

CancerGeneNet ( https://signor.uniroma2.it/CancerGeneNet/ ) is a resource that links genes
that are frequently mutated in cancers to cancer phenotypes. The resource takes advantage …

Multiple chemical sensitivity (MCS) is a common clinical diagnosis in western populations and
its symptoms are thought to be mainly related to chemical compounds exposure. Although …

Purpose Considering recent advances in central cognitive- and age-related processing
interfering with balance and sensory reweighting in uncompensated vestibular disorders, …

Identification of modules in molecular networks is at the core of many current analysis
methods in biomedical research. However, how well different approaches identify disease-…

Motivation Mass spectrometry-based phosphoproteomics can routinely identify and quantify
thousands of phosphorylated peptides from a single experiment. However interrogating …

Neoantigens are tumor-specific antigens able to induce T-cell responses, generated by
mutations in protein-coding regions of expressed genes. Previous studies demonstrated that …