Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …

Activation of the peripheral immune system elicits a coordinated response from the central
nervous system. Key to this immune to brain communication is that glia, microglia, and …

Nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central
nervous system, being expressed in neurons and non-neuronal cells, where they participate in …

All metazoans depend on the consumption of O 2 by the mitochondrial oxidative phosphorylation
system (OXPHOS) to produce energy. In addition, the OXPHOS uses O 2 to produce …

Microglia have emerged as important players in brain aging and pathology. To understand
how genetic risk for neurological and psychiatric disorders is related to microglial function, …

Mitochondria use oxygen as the final acceptor of the respiratory chain, but its incomplete
reduction can also produce reactive oxygen species (ROS), especially superoxide. Acute …

Agmatine, an endogenous neuromodulator, is a potential candidate to constitute an
adjuvant/monotherapy for the management of depression. A recent study by our group …

Scope We have studied if curcumin can protect glial cells under an oxidative stress and
inflammatory environment, which is known to be deleterious in neurodegeneration. Methods and …

Aims: A loss in brain acetylcholine and cholinergic markers, subchronic inflammation, and
impaired mitochondrial function, which lead to low-energy production and high oxidative stress…

Background Genetic mutations in beta-glucocerebrosidase (GBA) represent the major
genetic risk factor for Parkinson’s disease (PD). GBA participates in both the endo-lysosomal …