Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use 1 . Despite …

The incorporation of genomics into medicine is stimulating interest on the return of incidental
findings (IFs) from exome and genome sequencing. However, no large-scale study has yet …

Recommendations for laboratories to report incidental findings from genomic tests have
stimulated interest in such results. In order to investigate the criteria and processes for assigning …

Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for
cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 …

Accurate colorectal cancer (CRC) risk prediction models are critical for identifying individuals
at low and high risk of developing CRC, as they can then be offered targeted screening …

Background Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic and
environmental risk factors that disproportionately afflicts communities of color. Leveraging …

Purpose Assessing the risk of common, complex diseases requires consideration of clinical
risk factors as well as monogenic and polygenic risks, which in turn may be reflected in …

Purpose Discovering an incidental finding (IF) or secondary finding (SF) is a potential result
of genomic testing, but few data exist describing types and frequencies of SFs likely to …

The Electronic Medical Records and Genomics (eMERGE) network is a network of medical
centers with electronic medical records linked to existing biorepository samples for genomic …

Polygenic risk scores (PRSs) have improved in predictive performance, but several challenges
remain to be addressed before PRSs can be implemented in the clinic, including reduced …