User profiles for Elisabeth C. Kugler

Elisabeth Kugler

UCL
Verified email at ucl.ac.uk
Cited by 283

[HTML][HTML] The “neuro-glial-vascular” unit: the role of glia in neurovascular unit formation and dysfunction

EC Kugler, J Greenwood… - Frontiers in Cell and …, 2021 - frontiersin.org
The neurovascular unit (NVU) is a complex multi-cellular structure consisting of endothelial
cells (ECs), neurons, glia, smooth muscle cells (SMCs), and pericytes. Each component is …

Zebrafish vascular quantification: a tool for quantification of three-dimensional zebrafish cerebrovascular architecture by automated image analysis

EC Kugler, J Frost, V Silva, K Plant… - …, 2022 - journals.biologists.com
Zebrafish transgenic lines and light sheet fluorescence microscopy allow in-depth insights
into three-dimensional vascular development in vivo. However, quantification of the zebrafish …

Cerebrovascular endothelial cells form transient Notch‐dependent cystic structures in zebrafish

EC Kugler, M van Lessen, S Daetwyler, K Chhabria… - EMBO …, 2019 - embopress.org
We identify a novel endothelial membrane behaviour in transgenic zebrafish. Cerebral blood
vessels extrude large transient spherical structures that persist for an average of 23 min …

[HTML][HTML] Cerebrovascular development: mechanisms and experimental approaches

TJA Chico, EC Kugler - Cellular and Molecular Life Sciences, 2021 - Springer
The cerebral vasculature plays a central role in human health and disease and possesses
several unique anatomic, functional and molecular characteristics. Despite their importance, …

Therapeutic targeting of vascular malformation in a zebrafish model of hereditary haemorrhagic telangiectasia

…, K Plant, EC Kugler, C Doh… - Disease Models & …, 2023 - journals.biologists.com
Hereditary haemorrhagic telangiectasia (HHT) causes arteriovenous malformations (AVMs)
in multiple organs to cause bleeding, neurological and other complications. HHT is caused …

Segmentation of the zebrafish brain vasculature from light sheet fluorescence microscopy datasets

EC Kugler, A Rampun, TJA Chico, PA Armitage - bioRxiv, 2020 - biorxiv.org
Light sheet fluorescent microscopy allows imaging of zebrafish vascular development in great
detail. However, interpretation of data often relies on visual assessment and approaches …

[HTML][HTML] Meeting in the middle: towards successful multidisciplinary bioimage analysis collaboration

…, RB MacDonald, KW Eliceiri, EC Kugler - Frontiers in …, 2022 - frontiersin.org
With an increase in subject knowledge expertise required to solve specific biological questions,
experts from different fields need to collaborate to address increasingly complex issues. …

Analytical Approaches for the Segmentation of the Zebrafish Brain Vasculature

EC Kugler, A Rampun, TJA Chico… - Current …, 2022 - Wiley Online Library
With advancements in imaging techniques, data visualization allows new insights into
fundamental biological processes of development and disease. However, although biomedical …

TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome

…, H Kett, M Habdank, CM Kugler… - Blood, The Journal …, 2012 - ashpublications.org
To assess the frequency of TP53 alterations and their correlation with other genetic changes
and outcome in acute myeloid leukemia with complex karyotype (CK-AML), we performed …

Introducing garmi-a service robotics platform to support the elderly at home: Design philosophy, system overview and first results

…, B Loinger, T Loibl, C Kugler, C Calafell… - IEEE Robotics and …, 2021 - ieeexplore.ieee.org
This letter introduces GARMI, a service robotics platform conceptualized with a focus on
assisting elderly at home. GARMI is designed to provide support with household tasks, as an …