[HTML][HTML] A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides

…, LK Thompson, A Kreymerman, EM Ricci-Blair… - Nature …, 2023 - nature.com
Parkinson’s disease (PD) is a complex neurodegenerative disease with etiology rooted in
genetic vulnerability and environmental factors. Here we combine quantitative epidemiologic …

[HTML][HTML] An insulin-regulated arrestin domain protein controls hepatic glucagon action

…, MC Okawa, VY Melnik, EM Ricci-Blair… - Journal of Biological …, 2023 - ASBMB
Glucagon signaling is essential for maintaining normoglycemia in mammals. The arrestin
fold superfamily of proteins controls the trafficking, turnover, and signaling of transmembrane …

Analysis of Cre-mediated genetic deletion of Gdf11 in cardiomyocytes of young mice

…, R Sereda, L Peng, EM Ricci-Blair… - American Journal …, 2019 - journals.physiology.org
Administration of active growth differentiation factor 11 (GDF11) to aged mice can reduce
cardiac hypertrophy, and low serum levels of GDF11 measured together with the related protein…

Discovery adductomics provides a comprehensive portrait of tissue-, age-and sex-specific DNA modifications in rodents and humans

…, J Garbern, H Elwell, F Cao, EM Ricci-Blair… - Nucleic Acids …, 2023 - academic.oup.com
DNA damage causes genomic instability underlying many diseases, with traditional analytical
approaches providing minimal insight into the spectrum of DNA lesions in vivo. Here we …

[PDF][PDF] Thioredoxin interacting protein is required for a chronic energy-rich diet to promote intestinal fructose absorption

…, JP Lewandowski, AB Schmider, EM Ricci-Blair… - IScience, 2020 - cell.com
Increased consumption of fats and added sugars has been associated with an increase in
metabolic syndromes. Here we show that mice chronically fed an energy-rich diet (ERD) with …

[HTML][HTML] Effect of dietary fat and sucrose consumption on cardiac fibrosis in mice and rhesus monkeys

…, J Das, AC Wang, KK Phu, SH Kiehm, EM Ricci-Blair… - JCI insight, 2019 - ncbi.nlm.nih.gov
Calorie restriction (CR) improved health span in 2 longitudinal studies in nonhuman primates
(NHPs), yet only the University of Wisconsin (UW) study demonstrated an increase in …

[HTML][HTML] Soluble interleukin-13rα1: A circulating regulator of glucose

…, CC O'Meara, EM Ricci-Blair… - American Journal …, 2017 - journals.physiology.org
Soluble IL-13 receptor-α1, or sIL13rα1, is a soluble protein that binds to interleukin-13 (IL-13)
that has been previously described in mice. The function of sIL13rα1 remains unclear, but it …

Tissue-and sex-specific DNA damage tracks aging in rodents and humans

…, JG Varela, J Garbern, H Elwell, F Cao, EM Ricci-Blair… - bioRxiv, 2022 - biorxiv.org
DNA damage causes genomic instability underlying many human diseases. Traditional
approaches to DNA damage analysis provide minimal insights into the spectrum of disease- …

Impact of dietary fat and sucrose consumption on cardiac fibrosis in rhesus monkeys and mice

…, KK Phu, SH Kiehm, EM RicciBlair… - The FASEB …, 2019 - Wiley Online Library
Calorie restriction (CR) improved healthspan in two longitudinal studies in nonhuman
primates (NHPs) aimed at investigating the effect of this nutritional intervention on markers of …

Do phenothiazines possess antimicrobial and efflux inhibitory properties?

EM Grimsey, LJV Piddock - FEMS Microbiology Reviews, 2019 - academic.oup.com
Antibiotic resistance is a global health concern; the rise of drug-resistant bacterial infections
is compromising the medical advances that resulted from the introduction of antibiotics at the …