Cohesin is a protein complex that is required to hold sister chromatids together. Cleavage of
the Scc1 subunit of cohesin by the protease separase releases the complex from …

The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues is an
important biological regulatory mechanism. In the context of genome integrity, signaling …

In this study we have analysed AtASY3, a coiled-coil domain protein that is required for
normal meiosis in Arabidopsis. Analysis of an Atasy3-1 mutant reveals that loss of the protein …

Protein expression and turnover are controlled through a complex interplay of transcriptional,
post-transcriptional and post-translational mechanisms to enable spatial and temporal …

An estimated one-third of all proteins in higher eukaryotes are regulated by phosphorylation
by protein kinases (PKs). Although plant genomes encode more than 1000 PKs, the …

Most regulatory pathways are governed by the reversible phosphorylation of proteins. Recent
developments in mass spectrometry-based technology allow the large-scale analysis of …

Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin
complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is …

Meiotic chromosomes are organized into linear looped chromatin arrays by a protein axis
localized along the loop-bases. Programmed remodelling of the axis occurs during prophase I …

During meiotic prophase I, sister chromatids are arranged in a loop-base array along a
proteinaceous structure, called the meiotic chromosome axis. This structure is essential for …

Protein phosphorylation is a key regulatory mechanism of cellular signalling processes. The
analysis of phosphorylated proteins and the characterisation of phosphorylation sites under …