Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells
DJ Kurz, S Decary, Y Hong, E Trivier… - Journal of cell …, 2004 - journals.biologists.com
Replicative senescence and oxidative stress have been implicated in ageing, endothelial
dysfunction and atherosclerosis. Replicative senescence is determined primarily by telomere …
dysfunction and atherosclerosis. Replicative senescence is determined primarily by telomere …
Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome
E Trivier, D De Cesare, S Jacquot, S Pannetier… - Nature, 1996 - nature.com
THE Coffin-Lowry syndrome (CLS), an X-linked disorder, is characterized by severe psychomotor
retardation, facial and digital dysmorphisms, and progressive skeletal deformations 1 . …
retardation, facial and digital dysmorphisms, and progressive skeletal deformations 1 . …
LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells
…, D Crighton, A Li, I König, J Munro, E Trivier… - Journal of Cell …, 2010 - rupress.org
LIM kinases 1 and 2 (LIMK1/2) are centrally positioned regulators of actin cytoskeleton
dynamics. Using siRNA-mediated knockdown or a novel small molecule inhibitor, we show LIMK …
dynamics. Using siRNA-mediated knockdown or a novel small molecule inhibitor, we show LIMK …
Expression analysis of RSK gene family members: the RSK2 gene, mutated in Coffin–Lowry syndrome, is prominently expressed in brain structures essential for …
M Zeniou, T Ding, E Trivier… - Human molecular …, 2002 - academic.oup.com
Coffin–Lowry syndrome (CLS) is characterized by cognitive impairment, characteristic facial
and digital findings and skeletal anomalies. The gene implicated in CLS encodes RSK2, a …
and digital findings and skeletal anomalies. The gene implicated in CLS encodes RSK2, a …
Optimization of TEAD P-site binding fragment hit into in vivo active lead MSC-4106
…, N Pearson, S Sirohi, M Hooker, E Trivier… - Journal of Medicinal …, 2022 - ACS Publications
The dysregulated Hippo pathway and, consequently, hyperactivity of the transcriptional YAP/TAZ-TEAD
complexes is associated with diseases such as cancer. Prevention of YAP/TAZ-…
complexes is associated with diseases such as cancer. Prevention of YAP/TAZ-…
Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase (AKR1C3)
…, DG Brooke, S Silva, LJM Rigoreau, E Trivier… - Bioorganic & Medicinal …, 2014 - Elsevier
Inhibitors of the aldo–keto reductase enzyme AKR1C3 are of interest as potential drugs for
leukemia and hormone-related cancers. A series of non-carboxylate morpholino(…
leukemia and hormone-related cancers. A series of non-carboxylate morpholino(…
[HTML][HTML] RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6
E Trivier, TS Ganesan - Journal of Biological Chemistry, 2002 - ASBMB
RYK is an atypical orphan receptor tyrosine kinase that lacks detectable kinase activity.
Nevertheless, using a chimeric receptor approach, we previously found that RYK can signal via …
Nevertheless, using a chimeric receptor approach, we previously found that RYK can signal via …
Fibroblast growth factor-2, but not vascular endothelial growth factor, upregulates telomerase activity in human endothelial cells
DJ Kurz, Y Hong, E Trivier, HL Huang… - … , and vascular biology, 2003 - Am Heart Assoc
Objective— Telomerase plays a major role in the control of replicative capacity, a critical
property for successful angiogenesis and maintenance of endothelial integrity. In this study, we …
property for successful angiogenesis and maintenance of endothelial integrity. In this study, we …
[HTML][HTML] PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer
…, BM Simões, I Dragoni, R NicAmhlaoibh, E Trivier… - Cancer letters, 2019 - Elsevier
Despite the effectiveness of endocrine therapies to treat estrogen receptor-positive (ER+)
breast tumours, two thirds of patients will eventually relapse due to de novo or acquired …
breast tumours, two thirds of patients will eventually relapse due to de novo or acquired …
3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: Highly Potent and Selective Inhibitors of the Type 5 17-β-Hydroxysteroid Dehydrogenase AKR1C3
…, AP Turnbull, LJM Rigoreau, E Trivier… - Journal of medicinal …, 2012 - ACS Publications
A high-throughput screen identified 3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acid
as a novel, highly potent (low nM), and isoform-selective (1500-fold) inhibitor of aldo-keto …
as a novel, highly potent (low nM), and isoform-selective (1500-fold) inhibitor of aldo-keto …