Chloride intracellular channel 4 (CLIC4) is a cytosolic protein implicated in diverse actin-based
processes, including integrin trafficking, cell adhesion, and tubulogenesis. CLIC4 is …

Chloride intracellular channel protein 4 (CLIC4) exists in both soluble and membrane-associated
forms, and is implicated in diverse cellular processes, ranging from ion channel …

Clathrin lattices at the plasma membrane coat both invaginated and flat regions forming
clathrin-coated pits and clathrin plaques, respectively. The function and regulation of clathrin-…

How the cell converts graded signals into threshold‐activated responses is a question of
great biological relevance. Here, we uncover a nonlinear modality of epidermal growth factor …

Ubiquitination of the epidermal growth factor receptor (EGFR) that occurs when Cbl and
Grb2 bind to three phosphotyrosine residues (pY1045, pY1068 and pY1086) on the receptor …

Cl − intracellular channels (CLICs) are a family of six evolutionary conserved cytosolic proteins
that exist in both soluble and membrane-associated forms; however, their functions have …

Clathrin-mediated endocytosis (CME) is the major pathway of epidermal growth factor receptor
(EGFR) internalization. It is commonly believed that CME mediates long-term attenuation …

Invadosomes are actin-rich membrane protrusions that degrade the extracellular matrix to
drive tumor cell invasion. Key players in invadosome formation are c-Src and Rho family …

The activity, localization and fate of many cellular proteins are regulated through ubiquitination,
a process whereby one or more ubiquitin (Ub) monomers or chains are covalently …

We have previously shown that Kupffer cells (KCs) of Rana esculenta L. possess
melanogenic ability. The melanogenic enzyme activities in these cells are different from those …