Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a
deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our …

Malignant pleural mesothelioma (MPM) is a rare, aggressive cancer caused by asbestos
exposure. An inherited predisposition has been suggested to explain multiple cases in the …

Inherited loss‐of‐function mutations in the BAP1 oncosuppressor gene are responsible for
an inherited syndrome with predisposition to malignant mesothelioma (MM), uveal and …

Asbestos exposure is the main risk factor for malignant pleural mesothelioma (MPM), a rare
aggressive tumor. Nevertheless, only 5–17% of those exposed to asbestos develop MPM, …

Pathogenic germline variants in the BAP1 tumor suppressor gene can cause a cancer
syndrome called BAP1 tumor predisposition syndrome (BAP1‐TPDS), which is characterized by …

Introduction Malignant pleural mesothelioma (MPM) is a tumour associated with asbestos
exposure. Approximately, 10% of patients with MPM carry a germline pathogenic variant (PV), …

Asbestos exposure is the main risk factor for malignant pleural mesothelioma (MPM), a rare
aggressive tumor. Nevertheless, on average less than 10% of subjects highly exposed to …

Objectives Osteoarthritis (OA) is a complex disease, but its genetic aetiology remains poorly
characterised. To identify novel susceptibility loci for OA, we carried out a genome-wide …

The role of rare variants in complex traits remains uncharted. Here, we conduct deep whole
genome sequencing of 1457 individuals from an isolated population, and test for rare variant …

Introduction Malignant pleural mesothelioma (MPM) is an aggressive tumor strongly associated
with asbestos exposure. Patients are usually diagnosed when current treatments have …