10.7554/eLife.36258.001 The transcription factor ASCIZ (ATMIN, ZNF822) has an unusually
high number of recognition motifs for the product of its main target gene, the hub protein …

In animal gonads, the PIWI-interacting RNA (piRNA) pathway guards genome integrity in
part through the co-transcriptional gene silencing of transposon insertions. In Drosophila …

Deamidation is a major age-related modification in the human lens that is highly prevalent in
crystallins isolated from the insoluble fraction of cataractous lenses and also causes protein …

The nucleocapsid (N) protein of SARS-CoV-2 binds viral RNA, condensing it inside the
virion, and phase separating with RNA to form liquid–liquid condensates. There is little …

Dynein light chain 8 (LC8) interacts with intrinsically disordered proteins (IDPs) and influences
a wide range of biological processes. It is becoming apparent that among the numerous …

Multistep protein-protein interactions underlie most biological processes, but their characterization
through methods such as isothermal titration calorimetry (ITC) is largely confined to …

The mechanism by which the inflammatory enzyme prostaglandin H 2 synthase-1 (PGHS-1)
deactivates remains undefined. This study aimed to determine the stabilizing parameters of …

LC8, a ubiquitous and highly conserved hub protein, binds over 100 proteins involved in
numerous cellular functions, including cell death, signaling, tumor suppression, and viral …

Kinesin-14s are microtubule-based motor proteins that play important roles in mitotic
spindle assembly [1]. Ncd-type kinesin-14s are a subset of kinesin-14 motors that exist as …

As the only major retrograde transporter along microtubules, cytoplasmic dynein plays crucial
roles in the intracellular transport of organelles and other cargoes. Central to the function …