De novo and inherited rare genetic disorders (RGDs) are a major cause of human morbidity,
frequently involving neuropsychiatric symptoms. Recent advances in genomic technologies …

Importance; Copy number variants (CNVs) classified as pathogenic are identified in 10% to
15% of patients referred for neurodevelopmental disorders. However, their effect sizes on …

Objective: Deleterious copy number variants (CNVs) are identified in up to 20% of individuals
with autism. However, levels of autism risk conferred by most rare CNVs remain unknown. …

Genomic copy number variants (CNVs) are routinely identified and reported back to patients
with neuropsychiatric disorders, but their quantitative effects on essential traits such as …

16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum
Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but …

Background Language delay is one of the major referral criteria for an autism evaluation.
Once an autism spectrum diagnosis is established, the language prognosis is among the main …

Background The 15q11.2 deletion is frequently identified in the neurodevelopmental clinic.
Case–control studies have associated the 15q11.2 deletion with neurodevelopmental …

Many copy number variants (CNVs) confer risk for the same range of neurodevelopmental
symptoms and psychiatric conditions including autism and schizophrenia. Yet, to date …

Copy number variations (CNVs) are rare genomic deletions and duplications that can affect
brain and behaviour. Previous reports of CNV pleiotropy imply that they converge on shared …

Objective: Copy number variants (CNVs) are strongly associated with neurodevelopmental
and psychotic disorders. Early-onset psychosis (EOP), where symptoms appear before 18 …