… Author links open overlay panel Agnes Görlach a b , Elitsa Y. Dimova c , Andreas Petry a
b , Antonio Martínez-Ruiz d , Pablo Hernansanz-Agustín d e , Anabela P. Rolo f , Carlos M. …

The hypoxia-inducible factor α-subunits (HIFα) are key transcription factors in the mammalian
response to oxygen deficiency. The HIFα regulation in response to hypoxia occurs …

Objective— Small-molecule hypoxia-inducible factor prolyl 4-hydroxylase (HIF-P4H) inhibitors
are being explored in clinical studies for the treatment of anemia. HIF-P4H-2 (also known …

The NRF2 pathway is frequently activated in various cancer types, yet a comprehensive
analysis of its effects across different malignancies is currently lacking. We developed a NRF2 …

Obesity is associated with an inflammatory status and linked with a number of pathophysiological
complications among them cardiovascular disease, type 2 diabetes mellitus, or the …

Activation of the hypoxia-inducible factor (HIF) pathway reprograms energy metabolism.
Hemoglobin (Hb) is the main carrier of oxygen. Using its normal variation as a surrogate …

Plasminogen activator inhibitor-1 (PAI-1) controls the regulation of the fibrinolytic system in
blood by inhibiting both urokinase-type and tissue-type plasminogen activators. Enhanced …

The circadian clock and the hypoxia-signaling pathway are regulated by an integrated
interplay of positive and negative feedback limbs that incorporate energy homeostasis and …

Resveratrol, a polyphenol derived from grapes, exerts important effects on glucose and lipid
metabolism, yet detailed mechanisms mediating these effects remain unknown. The liver …

Plasminogen activator inhibitor-1 (PAI-1) is the major physiological inhibitor of urokinase-type
and tissue-type plasminogen activators. It has gained special interest among clinicians …