Division and differentiation of natural antibody-producing cells in mouse spleen
Y Yang, JW Tung, EEB Ghosn… - Proceedings of the …, 2007 - National Acad Sciences
B-1a cells reside in both the peritoneal cavity and the spleen. LPS stimulates splenic B-1a
to differentiate to plasma cells producing natural IgM specific for microbial and self antigens. …
to differentiate to plasma cells producing natural IgM specific for microbial and self antigens. …
[HTML][HTML] Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma
Myeloid cells comprise the majority of immune cells in tumors, contributing to tumor growth
and therapeutic resistance. Incomplete understanding of myeloid cells response to tumor …
and therapeutic resistance. Incomplete understanding of myeloid cells response to tumor …
Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires
10.7554/eLife.09083.001 Processes that define immunoglobulin repertoires are commonly
presumed to be the same for all murine B cells. However, studies here that couple high-…
presumed to be the same for all murine B cells. However, studies here that couple high-…
[HTML][HTML] Earth mover's distance (EMD): a true metric for comparing biomarker expression levels in cell populations
…, S Meehan, C Meehan, J Waters, EEB Ghosn… - PloS one, 2016 - journals.plos.org
Changes in the frequencies of cell subsets that (co)express characteristic biomarkers, or
levels of the biomarkers on the subsets, are widely used as indices of drug response, disease …
levels of the biomarkers on the subsets, are widely used as indices of drug response, disease …
Ultraselective carbon nanotubes for photoacoustic imaging of inflamed atherosclerotic plaques
…, MV McConnell, EEB Ghosn… - Advanced functional …, 2021 - Wiley Online Library
Disruption of vulnerable atherosclerotic plaques often leads to myocardial infarction and
stroke, the leading causes of morbidity and mortality in the United States. A diagnostic method …
stroke, the leading causes of morbidity and mortality in the United States. A diagnostic method …
Transcriptional reprogramming of infiltrating neutrophils drives lung pathology in severe COVID-19 despite low viral load
…, RM Tirouvanziam, EEB Ghosn - Blood …, 2023 - ashpublications.org
… Eliver EB Ghosn Eliver EB Ghosn … Tirouvanziam, Eliver EB Ghosn; Transcriptional
reprogramming of infiltrating neutrophils drives lung pathology in severe COVID-19 despite low viral …
reprogramming of infiltrating neutrophils drives lung pathology in severe COVID-19 despite low viral …
Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy
Rationale: Basophils contribute to anaphylaxis and allergies. We examined the utility of
assessing basophil-associated surface antigens (CD11b/CD63/CD123/CD203c/CD294) in …
assessing basophil-associated surface antigens (CD11b/CD63/CD123/CD203c/CD294) in …
[HTML][HTML] Mast cell repopulating ability is lost during the transition from pre-HSC to FL HSC
…, H Cheng, A Latorre, C Nishida, EEB Ghosn… - Frontiers in …, 2022 - frontiersin.org
Recent advances in developmental immunology have revealed a hematopoietic stem cell (HSC)-independent
origin for various innate immune lineages, including mast cells (MCs). It is …
origin for various innate immune lineages, including mast cells (MCs). It is …
[HTML][HTML] Development of B cells and erythrocytes is specifically impaired by the drug celastrol in mice
Background Celastrol, an active compound extracted from the root of the Chinese medicine “Thunder
of God Vine” (Tripterygium wilfordii), exhibits anticancer, antioxidant and anti-…
of God Vine” (Tripterygium wilfordii), exhibits anticancer, antioxidant and anti-…
[HTML][HTML] Profiling the peripheral immune response to ex vivo TNF stimulation in untreated juvenile idiopathic arthritis using single cell RNA sequencing
…, LA Ponder, S Chandrakasan, EEB Ghosn… - Pediatric …, 2023 - Springer
Background Juvenile Idiopathic Arthritis (JIA) is an autoimmune disease with a heterogenous
clinical presentation and unpredictable response to available therapies. This personalized …
clinical presentation and unpredictable response to available therapies. This personalized …