Axial elongation of the neural tube is crucial during mammalian embryogenesis for anterior-posterior
body axis establishment and subsequent spinal cord development, but these …

The ductal system of the salivary gland has long been postulated to be resistant to radiation-induced
damage, a common side effect incurred by head and neck cancer patients …

Salivary proteins are essential for maintaining health in the oral cavity and proximal digestive
tract, and they serve as potential diagnostic markers for monitoring human health and …

Acinar cells are the principal secretory units of multiple exocrine organs. A single-cell, layered,
lumenized acinus forms from a large cohort of epithelial progenitors that must initiate and …

Salivary gland acinar cells are severely depleted after radiotherapy for head and neck cancer,
leading to loss of saliva and extensive oro-digestive complications. With no regenerative …

Corneal architecture is essential for vision and is greatly perturbed by the absence of tears
due to the highly prevalent disorder dry eye. With no regenerative therapies available, …

Recent advances in tissue clearing methodologies have enabled three-dimensional (3D)
visualization of the ovary and, consequently, in-depth exploration of the dynamic changes …

The neural crest (NC) is highly multipotent and generates diverse lineages in the developing
embryo. However, spatiotemporally distinct NC populations display differences in fate …

Autoimmune-mediated dry eye disease is a pathological feature of multiple disorders
including Sjögren's syndrome, lupus and rheumatoid arthritis that has a life-long, detrimental …

Sjögren’s syndrome (SS) is characterized by extensive lymphocytic infiltration of the salivary
and lacrimal gland (LG), resulting in acinar cell destruction and organ dysfunction. The …