The reference human genome sequence set the stage for studies of genetic variation and
its association with human disease, but epigenomic studies lack a similar reference. To …

The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for sporadic
Alzheimer's disease (sAD). However, the cell-type-specific functions of APOE4 in relation to …

Neuronal activity causes the rapid expression of immediate early genes that are crucial for
experience-driven changes to synapses, learning, and memory. Here, using both molecular …

Alzheimer’s disease (AD) is a severe 1 age-related neurodegenerative disorder characterized
by accumulation of amyloid-β plaques and neurofibrillary tangles, synaptic and neuronal …

Accumulation of tau and amyloid-β are two pathologic hallmarks of Alzheimer’s disease. We
conducted an epigenome-wide association study using the histone 3 lysine 9 acetylation (…

DNA damage contributes to brain aging and neurodegenerative diseases. However, the
factors stimulating DNA repair to stave off functional decline remain obscure. We show that …

Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). The
RTT missense MECP2 R306C mutation prevents MeCP2 from interacting with the NCoR/…

Pervasive neuroinflammation occurs in many neurodegenerative diseases, including Alzheimer’s
disease (AD). SPI1/PU.1 is a transcription factor located at a genome-wide significant …

The histone deacetylase HDAC2, which negatively regulates synaptic gene expression and
neuronal plasticity, is upregulated in Alzheimer's disease (AD) patients and mouse models. …

Mutations in the MAPT gene, which encodes the tau protein, are associated with several
neurodegenerative diseases, including frontotemporal dementia (FTD), dementia with epilepsy, …