CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder

…, A Sahagun, CM Keeshen, C Lu, EC Hamada… - BioRxiv, 2022 - biorxiv.org
The majority of autism spectrum disorder (ASD) risk genes are associated with ASD due to
haploinsufficiency, where only one gene copy is functional. Here, using SCN2A …

Phylogenetic, genomic, and biogeographic characterization of a novel and ubiquitous marine invertebrate-associated Rickettsiales parasite, Candidatus …

JG Klinges, SM Rosales, R McMinds… - The ISME …, 2019 - academic.oup.com
… −C)/(G+C), with positive skew indicating overabundance of G over C and negative skew
indicating overabundance of C … over C and negative skew indicating overabundance of C over G …

Pharmacokinetics of calcitriol and maxacalcitol administered into peritoneal dialysate bags in peritoneal dialysis patients

C Hamada, K Hayashi, I Shou… - Peritoneal dialysis …, 2005 - journals.sagepub.com
Objectives It is well known that injection of calcitriol (CT) or maxacalcitol (OCT) is very
effective in hemodialysis patients with secondary hyperparathyroidism (2HPT). However, it is …

Ferritins: dynamic management of biological iron and oxygen chemistry

X Liu, EC Theil - Accounts of chemical research, 2005 - ACS Publications
Ferritins are spherical, cage-like proteins with nanocavities formed by multiple polypeptide
subunits (four-helix bundles) that manage iron/oxygen chemistry. Catalytic coupling yields …

Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis

TK Roepke, EC King, A Reyna-Neyra, M Paroder… - Nature medicine, 2009 - nature.com
… After coagulation of the remaining whole blood at 23 C for 30 min, we centrifuged the clotted
blood at 800g for 5–10 min at 4 C. We collected milk by hand 2 h after … Elizabeth C King …

Simulation to aid disaster planning and mitigation: Tools and techniques for water distribution managers and emergency planners

EC Bristow, K Brumbelow - Journal of Water Resources Planning …, 2013 - ascelibrary.org
… Although the Hamada equations of fire spread were directly … The original fire-spread equations,
following Hamada’s model, … rate proposed by the Hamada equations is used unchanged. …

The death effector domain protein family

BC Barnhart, JC Lee, EC Alappat, ME Peter - Oncogene, 2003 - nature.com
Apoptosis signaling is regulated and executed by specialized proteins that often carry
protein/protein interaction domains. One of these domains is the death effector domain (DED) that …

The role of progesterone signaling in the pathogenesis of uterine leiomyoma

JJ Kim, EC Sefton - Molecular and cellular endocrinology, 2012 - Elsevier
Uterine leiomyomas are benign tumors that originate from the myometrium. Evidence points
to ovarian steroid hormones, in particular, progesterone as major promoters of leiomyoma …

Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts

RF Buckley, EC Mormino, RE Amariglio… - Alzheimer's & …, 2018 - Elsevier
Introduction Our objective was to investigate the effect of sex on cognitive decline within the
context of amyloid β (Aβ) burden and apolipoprotein E genotype. Methods We analyzed sex-…

Risk of hepatocellular carcinoma after spontaneous clearance of hepatitis C virus and in noncirrhosis chronic hepatitis C patients with sustained virological response …

CC Hsu, H Gopalakrishna, M Mironova… - Clinical Infectious …, 2023 - academic.oup.com
In a hepatitis C virus (HCV)–controlled human infection model (CHIM), healthy volunteers are
inoculated with HCV and then treated. Residual hepatocellular carcinoma (HCC) risk after …