The lifespan of neutrophils is plastic and highly responsive to factors that regulate cellular
survival. Defects in neutrophil number and survival are common to both hematologic disorders …

TLRs detect conserved molecular patterns that are unique to microbes, enabling tailored
responses to invading pathogens and modulating a multitude of immunopathological conditions…

Endotoxin-induced neutrophil recruitment in humans and its potential regulation by CXCL8
clearance. This study examined the establishment of neutrophilic inflammation in humans. …

Human neutrophils express Toll‐like receptor 4 (TLR4) at low levels, and the role of this
receptor in neutrophil responses to microbial stimuli has been questioned. Genetic manipulation …

Exposure to respiratory pathogens is a leading cause of exacerbations of airway diseases
such as asthma and chronic obstructive pulmonary disease (COPD). Pellino-1 is an E3 …

Human rhinovirus (HRV) infections are major contributors to the healthcare burden
associated with acute exacerbations of chronic airway disease, such as chronic obstructive …

Human rhinoviruses (HRV) are a major cause of exacerbations of airways disease. Aspects
of cell signalling responses to HRV infection remain unclear, particularly with regard to …

Immunometabolism and regulation of mitochondrial reactive oxygen species (mROS)
control the immune effector phenotype of differentiated macrophages. Mitochondrial function …

RESULTS We show that Pellino-1 is expressed in the airways of normal subjects and those
with COPD. We found that Pellino-1 expression is induced 4-fold (p< 0.001) in response to …

Variation in CAPN10, the gene encoding the ubiquitously expressed cysteine protease
calpain-10, has been associated with type 2 diabetes in Mexican Americans and in two northern-…