Improving effector activity of antigen-specific T cells is a major goal in cancer immunotherapy.
Despite the identification of several effector T cell (T EFF )-driving transcription factors (TFs)…

CRISPR-based genetic screening has revolutionized cancer drug target discovery, yet
reliable, multiplex gene editing to reveal synergies between gene targets remains a major …

CD8 + T cell exhaustion (Tex) limits disease control during chronic viral infections and
cancer. Here, we investigated the epigenetic factors mediating major chromatin-remodeling …

Identifying molecular mechanisms of exhausted CD8 T cells (T ex ) is a key goal of improving
immunotherapy of cancer and other diseases. However, high-throughput interrogation of in …

The clinical benefit of T cell immunotherapies remains limited by incomplete understanding
of T cell differentiation and dysfunction. We generated an epigenetic and transcriptional atlas …

Improving effector activity of antigen specific T cells is a major goal in cancer immunotherapy.
Despite the identification of several effector T cell (T EFF )-driving transcription factors (TF), …

In di vi dual sho 1 di ng an intern a 1 or i entati on tend to attribute respons ibi 1 i ty for success
or fai lure to thems el ves, while people hol di ng an external orienta ti on usual ly state …

Adaptive immune cells play key roles in antiviral and antitumor responses, and CD8 T cells
are the central cell types during these processes. In different immunological conditions (eg …

… *Substantial data for the article resulted from a study conducted by Freilich, Leitner & Carlisle
for the Transportation Research Board and was entitled: S. Mark White, The Zoning and …

Some time has passed since Professor Freilich's critical analysis of the taking equation1 and
during that time, the Supreme Court has twice revisited some key factors of the formula. 2 …