Mutations in the SHANK3 gene have been discovered in autism spectrum disorder (ASD),
and the intellectual disability, Phelan‐McDermid Syndrome. This study leveraged a new rat …

SHANK3 is a synaptic scaffolding protein localized in the postsynaptic density and has a
crucial role in synaptogenesis and neural physiology. Deletions and point mutations in …

Background: Epidemiological data link traffic-related air pollution (TRAP) to increased risk
of Alzheimer’s disease (AD). Preclinical data corroborating this association are largely from …

Maternally derived copy number gains of human chromosome 15q11.2-q13.3 (Dup15q
syndrome or Dup15q) cause intellectual disability, epilepsy, developmental delay, hypotonia, …

Loss-of-function mutations in the X-linked endosomal Na + /H + exchanger 6 (NHE6) cause
Christianson syndrome in males. Christianson syndrome involves endosome dysfunction …

Angelman syndrome (AS) is a rare genetic disorder characterized by severe intellectual
disability, seizures, lack of speech, and ataxia. The gene responsible for AS was identified as …

Background Neurodevelopmental disorders (NDDs), including intellectual disability, attention
deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD), are pervasive, …

Angelman syndrome (AS) is a rare genetic neurodevelopmental disorder characterized by
intellectual disabilities, motor and balance deficits, impaired communication, and a happy, …

Epidemiological studies consistently implicate traffic-related air pollution (TRAP) and/or
proximity to heavily trafficked roads as risk factors for developmental delays and …

Angelman syndrome (AS) is a genetic neurodevelopmental disorder characterized by
developmental delay, lack of speech, seizures, intellectual disability, hypotonia, and motor …