The genus Legionella contains more than 50 species, of which at least 24 have been
associated with human infection. The best-characterized member of the genus, Legionella …

The human pathogens enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and
EHEC) share a unique mechanism of colonization that results from the concerted action of …

Proteins containing membrane attack complex/perforin (MACPF) domains play important roles
in vertebrate immunity, embryonic development, and neural-cell migration. In vertebrates, …

Successful infection by enteric bacterial pathogens depends on the ability of the bacteria to
colonize the gut, replicate in host tissues and disseminate to other hosts. Pathogens such as …

Many bacterial pathogens utilize a type III secretion system to deliver multiple effector proteins
into host cells. Here we found that the type III effectors, NleE from enteropathogenic E. coli …

Staphylococcus aureus frequently invades the human bloodstream, leading to life threatening
bacteremia and often secondary foci of infection. Failure of antibiotic therapy to eradicate …

Bacteria have mechanisms to export proteins for diverse purposes, including colonization of
hosts and pathogenesis. A small number of archetypal bacterial secretion machines have …

Despite the widely held belief that gastric acid serves as a barrier to bacterial pathogens, there
are almost no experimental data to support this hypothesis. We have developed a mouse …

Legionella pneumophila and L. longbeachae are two species of a large genus of bacteria
that are ubiquitous in nature. L. pneumophila is mainly found in natural and artificial water …

The genus Legionella comprises 65 species, among which Legionella pneumophila is a
human pathogen causing severe pneumonia. To understand the evolution of an environmental …