It has become widely accepted that the most dangerous cardiac arrhythmias are due to
reentrant waves, ie, electrical wave(s) that recirculate repeatedly throughout the tissue at a …

Modeling the dynamics of wave propagation in human ventricular tissue and studying wave
stability require models that reproduce realistic characteristics in tissue. We present a …

Controlling the complex spatio-temporal dynamics underlying life-threatening cardiac
arrhythmias such as fibrillation is extremely difficult, because of the nonlinear interaction of …

Ongoing developments in cardiac modelling have resulted, in particular, in the development
of advanced and increasingly complex computational frameworks for simulating cardiac …

We examine the utility of the action potential (AP) duration (APD) restitution curve slope in
predicting the onset of electrical alternans when electrotonic and memory effects are …

The heart is a nonlinear biological system that can exhibit complex electrical dynamics, complete
with period-doubling bifurcations and spiral and scroll waves that can lead to fibrillatory …

In this manuscript we review the state of cardiac cell modelling in the context of international
initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim …

In this article, we briefly describe how transmembrane currents and other cellular ionic
processes are modeled to produce action potentials. Then we discuss 45 models of cardiac cells …

Background— Electrically based therapies for terminating atrial fibrillation (AF) currently fall
into 2 categories: antitachycardia pacing and cardioversion. Antitachycardia pacing uses low…

We present a novel algorithm for modeling electrical wave propagation in anatomical models
of the heart. The algorithm uses a phase-field approach that represents the boundaries …