Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share key features,
including accumulation of the RNA-binding protein TDP-43. TDP-43 regulates RNA …

Cortical hyperexcitability and mislocalization of the RNA-binding protein TDP43 are highly
conserved features in amyotrophic lateral sclerosis (ALS). Nevertheless, the relationship …

Autophagy is an evolutionarily conserved pathway mediating the breakdown of cellular
proteins and organelles. Emphasizing its pivotal nature, autophagy dysfunction contributes to …

Transcribed nucleotide repeat expansions form detectable RNA foci in patient cells that
contribute to disease pathogenesis. The most widely used method for detecting RNA foci, …

We have cloned and analyzed two Emx genes from the lamprey Petromyzon marinus and
our findings provide insight into the patterns and developmental consequences of gene …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive
neurodegenerative disorders marked in most cases by the nuclear exclusion and cytoplasmic …

RNA-binding protein (RBP) dysfunction is a fundamental hallmark of amyotrophic lateral
sclerosis (ALS) and related neuromuscular disorders. Abnormal neuronal excitability is also a …

Cell cycle exit is required for proper differentiation in most cells and is critical for normal
development, tissue homeostasis, and tumor suppression. However, the mechanisms that link …

The analysis of morphological changes that occur in the nervous system during normal
aging could provide insight into cognitive decline and neurodegenerative disease. Previous …

RNA methylation at adenosine N6 (m6A) is one of the most common RNA modifications,
impacting RNA stability, transport, and translation. Previous studies uncovered RNA …