Although the importance of human genetic polymorphisms in therapeutic outcomes is well
established, the role of our 'second genome' (the microbiome) has been largely overlooked. In …

INTRODUCTION Parkinson’s disease is a debilitating neurological condition affecting more
than 1% of the global population aged 60 and above. The primary medication used to treat …

Conspectus In most modern organic chemistry reports, including many of ours, reaction
optimization schemes are typically presented to showcase how reaction conditions have been …

Although asymmetric catalysis is universally dependent on spatial interactions to impart
specific chirality on a given substrate, examination of steric effects in these catalytic systems …

The delineation of molecular properties that underlie reactivity and selectivity is at the core
of physical organic chemistry 1 , 2 , 3 , 4 , 5 , and this knowledge can be used to inform the …

Predicting site selectivity in C–H bond oxidation reactions involving heteroatom transfer is
challenged by the small energetic differences between disparate bond types and the subtle …

Diet is a critical determinant of variation in gut microbial structure and function, outweighing
even host genetics 1 , 2 – 3 . Numerous microbiome studies have compared diets with …

Plant-derived lignans, consumed daily by most individuals, are thought to protect against
cancer and other diseases 1 ; however, their bioactivity requires gut bacterial conversion to …

A broad series of fully characterized, well-defined silica-supported W metathesis catalysts
with the general formula [(≡SiO)W(NAr)(CHCMe 2 R)(X)] (Ar = 2,6-iPr 2 C 6 H 3 (Ar iPr ), 2,…

Despite the remarkable microbial diversity found within humans, our ability to link genes to
phenotypes is based upon a handful of model microorganisms. We report a comparative …