Synaptic activity-induced calcium (Ca 2+ ) influx and subsequent propagation into the
nucleus is a major way in which synapses communicate with the nucleus to regulate …

Highlights • Elevated retrotransposon-encoded RNAs and protein products are present in
several human neurodegenerative disorders. • Pathogenic forms of TDP43 lose their ability to …

Background Novel mechanisms through which pathogenic tau leads to neuronal toxicity
remain largely unexplored as therapeutic targets for tauopathies. Activation of retrotransposons …

Synaptic activity-induced calcium ion (Ca 2+) influx and subsequent propagation of Ca 2+
into the nucleus is a major way in which synapses communicate with the nucleus to regulate …

Deposition of tau protein aggregates in the brain of affected individuals is a defining feature
of “tauopathies,” including Alzheimer’s disease. Studies of human brain tissue and various …

… were conceptualized by Elizabeth Ochoa and Dr. Bess Frost. Elizabeth Ochoa performed …
in this dissertation under the name Elizabeth Ochoa Thomas are those of Elizabeth Ochoa. …

The mammalian brain is composed of diverse neuron types that play different functional
roles. Recent single-cell RNA sequencing approaches have led to a whole brain taxonomy of …

It is often said that we live under systems of injustice. But if so, who ought to combat them,
and why? Many in the world's liberal elite hold that only the perpetrators or the victims have …

Antigens recognized by T helper (Th) cells in the context of MHC class II molecules have
vaccine potential against cancer and infectious agents. We have described previously a …

This study examines the confidentiality practices of highly experienced, well-trained group
psychotherapists. A provocative finding was that practitioners rarely inform prospective clients …