In healthy cells, fusion and fission events participate in regulating mitochondrial morphology.
Disintegration of the mitochondrial reticulum into multiple punctiform organelles during …

Background This Phase 1/2a study evaluated the safety, immunogenicity, and efficacy of an
experimental malaria vaccine comprised of the recombinant Plasmodium falciparum protein …

Background: Most (70%–100%) ovarian carcinomas express high levels of the epidermal
growth factor receptor (EGFR). To examine the relationship between EGFR and the invasive …

Background Gene-based vaccination using prime/boost regimens protects animals and
humans against malaria, inducing cell-mediated responses that in animal models target liver …

Vaccine development has the potential to be accelerated by coupling tools such as systems
immunology analyses and controlled human infection models to define the protective …

Background The Plasmodium protein Cell-traversal protein for ookinetes and sporozoites (CelTOS)
plays an important role in cell traversal of host cells in both, mosquito and vertebrates…

Mutations in the ras genes occur in 20% of all human cancers. These genes, in turn, produce
mutated proteins that are unique to cancer cells, rendering them distinguishable from …

The multidrug resistance (MDR) proteins are member of the ATP-binding cassette superfamily
and are present in a majority of human tumors. Their activity is a crucial factor leading to …

The relevance of angiogenesis in tumor biology and as a therapeutic target is well
established. MFG-E8 (also termed lactadherin) and developmental endothelial locus 1 (Del1) …

The mechanism by which vaccine adjuvants enhance immune responses has historically
been considered to be the creation of an antigen depot. From here, the antigen is slowly …