We embarked on a study to delineate the behavioural changes in mice after 4 weeks of
voluntary exercise. As an initial behavioural characterization, we exposed the control and …

Complex interactions between periphery and the brain regulate food intake in mammals.
Cannabinoid type-1 (CB 1 ) receptor antagonists are potent hypophagic agents, but the sites …

A variety of test procedures are used in preclinical research on behavioral pharmacology
and to dissociate behavioral differences or pharmacologically induced behavioral alterations …

We investigated the interaction between behavioural dimensions and cognitive performance
in the inbred mouse strains C57BL/6 and DBA/2, which have previously been found to differ …

Background Leucine supplementation might have therapeutic potential in preventing diet-induced
obesity and improving insulin sensitivity. However, the underlying mechanisms are at …

Hypothalamic pro-opiomelanocortin (POMC) neurons are known to trigger satiety. However,
these neuronal cells encompass heterogeneous subpopulations that release γ-…

Objective High‐protein diets favor weight loss and its maintenance. Whether these effects
might be recapitulated by certain amino acids is unknown. Therefore, the impact of leucine …

Methods Genome-wide RNA expression data from the hippocampal tissues of four inbred
mouse strains (129S1/SvlmJ, C57LB/6J, DBA/2J and FVB/NJ) were treated with varying doses …

Objectives Mouse inbred strains vary in baseline performance in depression-related behaviour
tests, which were originally validated as tests of antidepressant response. Therefore, we …

BACKGROUND:: Antidepressant drugs are used as first-line treatment in depression, but
response has been shown to be highly heterogeneous, with drugs often failing to have the …