Mutations in the CEBPA gene are present in 7%–10% of human patients with acute myeloid
leukemia (AML). However, no genetic models exist that demonstrate their etiological …

This paper first explores a number of themes in the psychological system developed by the
Austrian-American psychologist, Egon Brunswik, focusing on those that had a formative …

The transcriptional regulators that couple interfollicular basal keratinocyte proliferation arrest
to commitment and differentiation are yet to be identified. Here we report that the basic …

The immunological synapse is a molecular hub that facilitates the delivery of three
activation signals, namely antigen, costimulation/corepression and cytokines, from antigen-presenting …

The C/EBPα transcription factor regulates hepatic nitrogen, glucose, lipid and iron metabolism.
However, how it is able to independently control these processes is not known. Here, we …

Simple Summary Pancreatic cancer has the worst survival of any human cancer. Checkpoint
blockade has not yielded much benefit in pancreatic cancer. We explored immune cell …

Ceramide is a key mediator of apoptosis during the cellular stress response which is also
involved in stroke-induced death. Transient occlusion of the middle cerebral artery (MCA) in …

Ligation of T cell receptor (TCR) to peptide–MHC (pMHC) complexes initiates signaling leading
to T cell activation and TCR ubiquitination. Ubiquitinated TCR is then either internalized …

CD95 (APO-1/Fas)-mediated apoptosis is pivotal in normal lymphocyte homeostasis and
mutations of CD95 cause a benign autoimmune lymphoproliferation syndrome (ALPS) in …

The ratio measured the degree of perceptual constancy. In its place, Brunswik (1940b) adopted
new tools from the Anglo-American statistical tradition–correlation and regression. Then, …