Estimates of biological age based on DNA methylation patterns, often referred to as “epigenetic
age”,“DNAm age”, have been shown to be robust biomarkers of age in humans. We …

Background— DNA methylation leaves a long-term signature of smoking exposure and is one
potential mechanism by which tobacco exposure predisposes to adverse health outcomes…

Ruth Loos and colleagues report findings from a meta-analysis of multiple studies examining
the extent to which physical activity attenuates effects of a specific gene variant, FTO, on …

Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, …

Height is a highly heritable, classic polygenic trait with approximately 700 common associated
variants identified through genome-wide association studies so far. Here, we report 83 …

The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …

Body composition during puberty is a marker of metabolic changes that occur during this
period of growth and maturation, and, thus, holds key information regarding current and future …

It has long been recognized that there are “critical periods” during mammalian development
when exposure to specific environmental stimuli are required in order to elicit the normal …

Reproductive longevity is essential for fertility and influences healthy ageing in women 1 , 2
, but insights into its underlying biological mechanisms and treatments to preserve it are …

Menopause timing has a substantial impact on infertility and risk of disease, including breast
cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in …