This article reviews the evidence from randomized, placebo‐controlled trials and meta‐analyses
of pharmacological treatments of the following anxiety disorders: generalized anxiety …

Autism spectrum disorders (ASDs) are a group of devastating neurodevelopmental syndromes
that affect up to 1 in 68 children. Despite advances in the identification of ASD risk genes, …

Autism spectrum disorder (ASD) is a complex developmental syndrome of unknown etiology.
Recent studies employing exome- and genome-wide sequencing have identified nine high-…

Congenital hydrocephalus (CH), characterized by enlarged brain ventricles, is considered a
disease of excessive cerebrospinal fluid (CSF) accumulation and thereby treated with …

Hundreds of human genes are associated with neurological diseases, but translation into
tractable biological mechanisms is lagging. Larval zebrafish are an attractive model to …

Zebrafish are increasingly being utilized as a model system to investigate the function of the
growing list of risk genes associated with neurodevelopmental disorders. This is due in …

Advancing from gene discovery in autism spectrum disorders (ASDs) to the identification of
biologically relevant mechanisms remains a central challenge. Here, we perform parallel in …

Background Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder
with a genetic risk component, yet identification of high-confidence risk genes has been …

Background It has previously been shown that specific microdeletions and microduplications,
many of which also associated with cognitive impairment (CI), can present with autism …

The lack of effective treatments for autism spectrum disorder (ASD) and congenital
hydrocephalus (CH) reflects the limited understanding of the biology underlying these common …