Developmental alterations of excitatory synapses are implicated in autism spectrum disorders
(ASDs). Here, we report increased dendritic spine density with reduced developmental …

Genetic studies have shown the association of Parkinson’s disease with alleles of the major
histocompatibility complex 1 , 2 , 3 . Here we show that a defined set of peptides that are …

The basis for selective death of specific neuronal populations in neurodegenerative
diseases remains unclear. Parkinson's disease (PD) is a synucleinopathy characterized by a …

Subsets of rodent neurons are reported to express major histocompatibility complex class I (MHC-I),
but such expression has not been reported in normal adult human neurons. Here …

The most common genetic risk factors for Parkinson’s disease (PD) are a set of heterozygous
mutant (MT) alleles of the GBA1 gene that encodes β-glucocerebrosidase (GCase), an …

Heterozygous mutations in GBA, the gene encoding the lysosomal enzyme glucosylceramidase
beta/β-glucocerebrosidase, comprise the most common genetic risk factor for Parkinson …

In addition to the appearance of senile plaques and neurofibrillary tangles, Alzheimer's disease
( AD ) is characterized by aberrant lipid metabolism and early mitochondrial dysfunction. …

Neurotransmission at dopaminergic synapses has been studied with techniques that provide
high temporal resolution, but cannot resolve individual synapses. To elucidate the spatial …

In Parkinson’s disease and other synucleinopathies, the elevation of α-synuclein phosphorylated
at Serine129 (pS129) is a widely cited marker of pathology. However, the physiological …

In the yeast Saccharomyces cerevisiae, the Snf1 protein kinase of the Snf1/AMP-activated
protein kinase (AMPK) family regulates a wide range of responses to stress caused by …