Metabolism is a major regulator of immune cell function, but it remains difficult to study the
metabolic status of individual cells. Here, we present Compass, an algorithm to characterize …

Infiltration of regulatory T (Treg) cells into many tumor types correlates with poor patient
prognoses. However, mechanisms of intratumoral Treg cell function remain to be elucidated. We …

Importance Conclusive intraoperative pathologic confirmation of diffuse infiltrative glioma
guides the decision to pursue definitive neurosurgical resection. Establishing the intraoperative …

Small cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer that remains
among the most lethal of solid tumor malignancies. Recent genomic sequencing studies have …

Though it is widely believed that chronic immunosuppressive medications increase the
severity of coronavirus disease 2019 (COVID‐19) illness, there is little data to support this. We …

Oncogenic KRAS activation, inflammation and p53 mutation are key drivers of pancreatic
cancer (PC) development. Here we report iASPP, an inhibitor of p53, as a paradoxical …

Although chromosomal deletions and inversions are important in cancer, conventional
methods for detecting DNA rearrangements require laborious indirect assays. Here we develop …

Traditional cloning methods have limitations on the number of DNA fragments that can be
simultaneously manipulated, which dramatically slows the pace of molecular assembly. Here …

Inducible expression of neoantigens in mice would enable the study of endogenous antigen-specific
naïve T cell responses in disease and infection, but has been difficult to generate …

Pathogenic autoantibodies contribute to tissue damage and clinical decline in autoimmune
disease. Follicular T cells are central regulators of germinal centers, although their …