Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm (MPN) of
childhood with a poor prognosis. Mutations in NF1, NRAS, KRAS, PTPN11 or CBL occur in 85% …

To understand the mechanisms that mediate germline genetic leukemia predisposition, we
studied the inherited ribosomopathy Shwachman-Diamond syndrome (SDS), a bone marrow …

Acute erythroid leukemia (AEL) is a high-risk leukemia of poorly understood genetic basis,
with controversy regarding diagnosis in the spectrum of myelodysplasia and myeloid leukemia…

While the majority of leukemia cases occur in the absence of any known predisposing factor,
there are germline mutations that significantly increase the risk of developing hematopoietic …

The wide variety of clinical manifestations of the genetic syndrome neurofibromatosis type 1
(NF1) are driven by overactivation of the RAS pathway. Mitogen-activated protein kinase …

Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative neoplasm of
childhood associated with a poor prognosis. Recently, massively parallel sequencing has …

Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative disorder of childhood
caused by mutations in the Ras pathway. Outcomes in JMML vary markedly from spontaneous …

Chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML)
are myelodysplastic syndrome (MDS)/myeloproliferative neoplasm (MPN) overlap disorders …

Patients with MLLr B-ALL have poor prognoses despite recent immunotherapy advances.
Here, surface proteomics identifies CD72 as being enriched on MLLr B-ALL but also widely …

Purpose: Known clinical and genetic markers have limitations in predicting disease course
and outcome in juvenile myelomonocytic leukemia (JMML). DNA methylation patterns in …