Complex I (NADH:ubiquinone oxidoreductase) is the first enzyme of the mitochondrial
respiratory chain and is composed of 45 subunits in humans, making it one of the largest known …

Purpose: Although cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors significantly extend
tumor response in patients with metastatic estrogen receptor–positive (ER + ) breast cancer, …

Bone marrow is a preferred metastatic site for multiple solid tumours and is associated with
poor prognosis and significant morbidity. Accumulating evidence indicates that cancer cells …

Biogenesis of complex IV of the mitochondrial respiratory chain requires assembly factors
for subunit maturation, co-factor attachment and stabilization of intermediate assemblies. A …

The ability to genetically modify CD8 T cells using viral gene delivery has facilitated the
development of next generation of cancer immunotherapies such as chimeric Ag receptor (CAR) …

KAT6A, and its paralog KAT6B, are histone lysine acetyltransferases (HAT) that acetylate
histone H3K23 and exert an oncogenic role in several tumor types including breast cancer …

The ability to genetically modify CD8 T cells using viral gene delivery has facilitated the
development of next generation of cancer immunotherapies such as chimeric antigen receptor (…

Inheritance of a BRCA2 pathogenic variant conveys a substantial life-time risk of breast
cancer. Identification of the cell(s)-of-origin of BRCA2-mutant breast cancer and targetable …

Mitochondria are complex organelles containing 13 proteins encoded by mitochondrial
DNA and over 1000 proteins encoded on nuclear DNA. Many mitochondrial proteins are …

The cytokine granulocyte-macrophage-colony stimulating factor (GM-CSF) possesses the
capacity to differentiate monocytes into macrophages (MØs) with opposing functions, namely, …