Salamanders serve as important tetrapod models for developmental, regeneration and
evolutionary studies. An extensive molecular toolkit makes the Mexican axolotl (Ambystoma …

During limb regeneration adult tissue is converted into a zone of undifferentiated progenitors
called the blastema that reforms the diverse tissues of the limb. Previous experiments have …

For many years the mammalian CNS has been seen as an organ that is unable to regenerate.
However, it was also long known that lower vertebrate species are capable of impressive …

The ability of animals to regenerate missing parts is a dramatic and poorly understood aspect
of biology. The sources of new cells for these regenerative phenomena have been sought …

To understand how microtubules are generated in the growth cone, we have imaged
fluorescently tagged microtubules in living frog embryonic neurons. The neurons were labeled by …

INTRODUCTION Axolotls (Ambystoma mexicanum) and other salamanders are the only
tetrapods that can regenerate whole limbs. During this complex process, changes in gene …

Salamanders regenerate appendages via a progenitor pool called the blastema. The
cellular mechanisms underlying regeneration of muscle have been much debated but have …

Foreign environments may induce adult stem cells to switch lineages and populate multiple
tissue types, but whether this mechanism is used for tissue repair remains uncertain. …

Abstract Model organisms are widely used in research as accessible and convenient systems
to study a particular area or question in biology. Traditionally only a handful of organisms …

Three-dimensional organoid constructs serve as increasingly widespread in vitro models for
development and disease modeling. Current approaches to recreate morphogenetic …