Gastrulation is the fundamental process in all multicellular animals through which the basic
body plan is first laid down 1 , 2 , 3 – 4 . It is pivotal in generating cellular diversity …

Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly
characterized. In the present study, we employed DNA fiber analysis to investigate how …

Gastrulation is the fundamental process during the embryogenesis of all multicellular
animals through which the basic body plan is first laid down. It is pivotal in generating cellular …

Cell competition is emerging as a quality-control mechanism that eliminates unfit cells in a
wide range of settings from development to the adult. However, the nature of the cells …

Circadian rhythms are biological rhythms with a period close to 24 h. They become entrained
to the Earth’s solar day via different periodic cues, so-called zeitgebers. The entrainment of …

Cell competition is emerging as a quality control mechanism that eliminates unfit cells in a
wide range of settings from development to the adult. However, the nature of the cells …

Eukaryotic cells rely on mitochondria: organelles that are equipped with their own DNA (mtDNA)
to produce the energy they need. Each cell includes multiple mtDNA copies that are not …

A subset of hematopoietic stem cells with inherent myeloid and platelet bias (myHSC) is
positioned at the top of hematopoietic hierarchy and considered the most primitive. Notably, …

Single-cell analysis is an increasingly relevant approach in” omics” studies. In the last
decade, it has been applied to various fields, including cancer biology, neuroscience, and, …

Understanding cellular identity, heterogeneity and differentiation in mammals is crucial for
solving many long-standing questions regarding regenerative medicine, developmental …