EGFR as a potential therapeutic target for a subset of muscle-invasive bladder cancers presenting a basal-like phenotype
…, ML Lepage, C Krucker, E Chapeaublanc… - Science translational …, 2014 - science.org
Muscle-invasive bladder carcinoma (MIBC) constitutes a heterogeneous group of tumors
with a poor outcome. Molecular stratification of MIBC may identify clinically relevant tumor …
with a poor outcome. Molecular stratification of MIBC may identify clinically relevant tumor …
[HTML][HTML] Independent component analysis uncovers the landscape of the bladder tumor transcriptome and reveals insights into luminal and basal subtypes
…, I Bernard-Pierrot, Y Lou, C Krucker, E Chapeaublanc… - Cell reports, 2014 - cell.com
Extracting relevant information from large-scale data offers unprecedented opportunities in
cancerology. We applied independent component analysis (ICA) to bladder cancer …
cancerology. We applied independent component analysis (ICA) to bladder cancer …
[HTML][HTML] A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression
…, M Sefta, C Desbrousses, E Chapeaublanc… - Nature …, 2021 - nature.com
Retinoblastoma is the most frequent intraocular malignancy in children, originating from a
maturing cone precursor in the developing retina. Little is known on the molecular basis …
maturing cone precursor in the developing retina. Little is known on the molecular basis …
[HTML][HTML] Deregulation of Rab and Rab effector genes in bladder cancer
JR Ho, E Chapeaublanc, L Kirkwood, R Nicolle… - PloS one, 2012 - journals.plos.org
Growing evidence indicates that Rab GTPases, key regulators of intracellular transport in
eukaryotic cells, play an important role in cancer. We analysed the deregulation at the …
eukaryotic cells, play an important role in cancer. We analysed the deregulation at the …
A siRNA screen identifies RAD21 , EIF3H , CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 …
SF Mahmood, N Gruel, E Chapeaublanc… - …, 2014 - academic.oup.com
RNA interference has boosted the field of functional genomics, by making it possible to carry
out ‘loss-of-function’ screens in cultured cells. Here, we performed a small interfering RNA …
out ‘loss-of-function’ screens in cultured cells. Here, we performed a small interfering RNA …
Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01
…, I Aerts, F Doz, N Cassoux, E Chapeaublanc… - Science translational …, 2019 - science.org
Retinoblastoma is a pediatric solid tumor of the retina activated upon homozygous inactivation
of the tumor suppressor RB1. VCN-01 is an oncolytic adenovirus designed to replicate …
of the tumor suppressor RB1. VCN-01 is an oncolytic adenovirus designed to replicate …
[HTML][HTML] Epigenomic mapping identifies an enhancer repertoire that regulates cell identity in bladder cancer through distinct transcription factor networks
Muscle-invasive bladder cancer (BLCA) is an aggressive disease. Consensus BLCA
transcriptomic subtypes have been proposed, with two major Luminal and Basal subgroups, …
transcriptomic subtypes have been proposed, with two major Luminal and Basal subgroups, …
A novel epigenetic phenotype associated with the most aggressive pathway of bladder tumor progression
…, J Zucman-Rossi, E Chapeaublanc… - Journal of the …, 2011 - academic.oup.com
Background Epigenetic silencing can extend to whole chromosomal regions in cancer. There
have been few genome-wide studies exploring its involvement in tumorigenesis. Methods …
have been few genome-wide studies exploring its involvement in tumorigenesis. Methods …
An FGFR 3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers
…, M Dorland‐Galliot, E Chapeaublanc… - EMBO molecular …, 2018 - embopress.org
FGFR 3 alterations (mutations or translocation) are among the most frequent genetic events
in bladder carcinoma. They lead to an aberrant activation of FGFR 3 signaling, conferring an …
in bladder carcinoma. They lead to an aberrant activation of FGFR 3 signaling, conferring an …
[HTML][HTML] FGFR3 mutational activation can induce luminal-like papillary bladder tumor formation and favors a male sex bias
…, C Dunois-Larde, ML Lepage, E Chapeaublanc… - European Urology, 2023 - Elsevier
Background Bladder cancer (BCa) is more common in men and presents differences in
molecular subtypes based on sex. Fibroblast growth factor receptor 3 (FGFR3) mutations are …
molecular subtypes based on sex. Fibroblast growth factor receptor 3 (FGFR3) mutations are …