In some recent studies, a view emerged that stochastic dynamics governing the switching of
cells from one differentiation state to another could be characterized by a peak in gene …

Methods that use homologous recombination to engineer the genome of C. elegans commonly
use strains carrying specific insertions of the heterologous transposon Mos1. A large …

Background A number of studies have established that stochasticity in gene expression
may play an important role in many biological phenomena. This therefore calls for further …

Our previous single-cell based gene expression analysis pointed out significant variations
of LDHA level during erythroid differentiation. Deeper investigations highlighted that a …

Background According to Waddington’s epigenetic landscape concept, the differentiation
process can be illustrated by a cell akin to a ball rolling down from the top of a hill (proliferation …

Background Cell differentiation requires the integration of two opposite processes, a stabilizing
cellular memory, especially at the transcriptional scale, and a burst of gene expression …

Background Gene expression is an inherently stochastic process, owing to its dynamic
molecular nature. Protein amount distributions, which can be acquired by cytometry using a …

Amino acid bioavailability impacts mRNA translation in a codon depending manner. Here,
we report that the anti-cancer MAPK inhibitors (MAPKi) decrease the intracellular …

Inference of Gene Regulatory Networks (GRNs) is a difficult and long-standing question in
Systems Biology. Numerous approaches have been proposed with the latest methods …

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