Immunogenic cell death (ICD) refers to an immunologically distinct process of regulated cell
death that activates, rather than suppresses, innate and adaptive immune responses. Such …

Cancer cells are embedded in the tumor microenvironment (TME), a complex ecosystem of
stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human lung …

Introduction: Activation of the MET pathway through MET amplifications or mutations is
present in 3–4% of stage IV non-squamous non-small cell lung cancers (NSCLC). High MET …

The ongoing COVID-19 pandemic has caused a global economic and health crisis. To
identify host factors essential for coronavirus infection, we performed genome-wide functional …

How the innate and adaptive host immune system miscommunicate to worsen COVID-19
immunopathology has not been fully elucidated. Here, we perform single-cell deep-immune …

The stromal compartment of the tumor microenvironment consists of a heterogeneous set of
tissue-resident and tumor-infiltrating cells, which are profoundly moulded by cancer cells. An …

Mutations or amplification of the MET proto-oncogene are involved in the pathogenesis of
several tumours 1 , 2 , 3 , 4 , which rely on the constitutive engagement of this pathway for their …

Epidemiological and clinical reports indicate that SARS-CoV-2 virulence hinges upon the
triggering of an aberrant host immune response, more so than on direct virus-induced cellular …

Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African
ancestry compared to women of European ancestry. In search of common risk alleles for …

Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species (human/mouse),
and models (in vivo/in vitro) remains poorly inventoried at the single-cell level. …