The tumour-suppressor gene p53 is frequently mutated in human cancers and is important in
the cellular response to DNA damage 1 , 2 . Although the p53 family members p63 and p73 …

The transcription factor E2F-1 induces both cell-cycle progression and, in certain settings,
apoptosis. E2F-1 uses both p53-dependent and p53-independent pathways to kill cells 1 , 2 , …

p63 and p73 are functionally and structurally related to the tumor suppressor p53. However,
their own role in tumor suppression is unclear. Given the p53-like properties of p63 and p73, …

Aberrant expression of microRNAs (miRNAs) and the enzymes that control their processing
have been reported in multiple biological processes including primary and metastatic …

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing
molecular features of squamous cell carcinomas (SCCs) from five sites associated with …

The production of the human papillomavirus type 16 (HPV-16) is intimately tied to the
differentiation of the host epithelium that it infects. Infection occurs in the basal layer of the …

The cellular mechanisms that regulate the maintenance of adult tissue stem cells are still
largely unknown. We show here that the p53 family member, TAp63, is essential for …

The study of human papillomavirus type 16 (HPV-16) replication has been impaired because
of the lack of a cell culture system that stably maintains viral replication. Recently, cervical …

The p53 tumor suppressor gene is the most frequently mutated gene in human cancers, and
germ-line p53 mutations cause a familial predisposition for cancer. Germ-line or sporadic …

The study of human papillomaviruses (HPVs) in cell culture has been hindered because of
the difficulty in recreating the three-dimensional structure of the epithelium on which the virus …